Polymeric microparticles in solid dispersion form containing the hormone triiodothyronine (T3) for treatment of hypothyroidism: development, synthesis and physical-chemical and morphological characterization
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Abstract
Hypothyroidism is a common metabolic disease, which presents a low concentration of thyroid hormone due to deficient synthesis and/or low sensitivity to hormones by its receptors, and its treatment is usually done with hormone replacement from Levothyroxine monotherapy (L-T4), a drug originated from the synthetic molecule of thyroxine that has a prohormone action. The active hormone for the thyroid gland is triiodothyronine (T3), but it is not widely used due to its rapid degradation in the body. Because of this, this work aimed to develop a solid dispersion with T3, this proposal being based on the expected increase in stability, therapeutic effect and, consequently, the half-life of the drug through microtechnology. The solid dispersion was synthesized with PEG 6000 and polysorbate 80 and prepared using the solvent evaporation method. Then, it was partially characterized physico-chemical and morphologically through analytical methods such as thermogravimetry (TG), differential scanning calorimetry (DSC), infrared absorption spectroscopy (IR), as well as by scanning electron microscopy (SEM), and such analyzes indicated the formation of an effective and innovative system for drug delivery.
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