Herbal medicines with possible actions on the immune system: a literature review

Conteúdo do artigo principal

Dante Ferreira de Oliveira
Giovanna Casati
Carlos Rocha Oliveira

Resumo

Herbal Medicine is proving itself to be a complementary and alternative type of treatment, other than conventional medication approaches. The use of plants, roots, seeds, and other various natural resources has proven their potentially high therapeutic values and expanding  healthcare treatments in a way that benefits all, especially patients with a weak immune system who may suffer from health complications, in which standard approaches no longer perform any improvement in their diagnosis or those who suffers from side effects caused by conventional drugs. The present review is mainly focused on the use of Herbal Medicine for treating a disease or preventing our immune system from breaking down by using different herbs to stabilize and regulate our immunity. Several herbal drugs have been studied and tested, proving to enhance the efficiency of immunotherapies and inhibit illness progression due to their powerful pharmacological active ingredients, which can also be combined with one another, performing an even stronger boost to our immune system and possibly fight against a disease or symptom. Since ages ago, herbs were used for healing illnesses, being unknown all the extensive benefits a single plant can provide, but at the present time, medicinal plants not only play their role to heal, but also, to regulate and treat with barely no side effect, in comparison to other chemical compounds, improving lifestyle and being a trustworthy approach all over the world.

Detalhes do artigo

Como Citar
1.
Ferreira de Oliveira D, Casati G, Oliveira CR. Herbal medicines with possible actions on the immune system: a literature review. Braz. J. Nat. Sci [Internet]. 25º de novembro de 2022 [citado 22º de junho de 2024];4(3):E165202 -, 1. Disponível em: https://bjns.com.br/index.php/BJNS/article/view/165
Seção
Artigo de revisão em fluxo contínuo
Biografia do Autor

Dante Ferreira de Oliveira, Universidade Anhembi Morumbi

 Anhembi Morumbi University, São Paulo-SP, Brazil.

Giovanna Casati, Universidade Anhembi Morumbi

Anhembi Morumbi University, São Paulo-SP, Brazil.

Carlos Rocha Oliveira, Universidade Anhembi Morumbi

 Anhembi Morumbi University, São Paulo-SP, Brazil.

Referências

- Catanzaro M, Corsini E, Rosini M, Racchi M, Lanni C. Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea. Molecules. 2018 Oct 26;23(11):2778. doi: 10.3390/molecules23112778. PMID: 30373170; PMCID: PMC6278270.

- Netea MG, Quintin J, van der Meer JW. Trained immunity: a memory for innate host defense. Cell Host Microbe. 2011 May 19;9(5):355-61. doi: 10.1016/j.chom.2011.04.006. PMID: 21575907.

- Parasuraman S, Thing GS, Dhanaraj SA. Polyherbal formulation: Concept of ayurveda. Pharmacogn Rev. 2014 Jul;8(16):73-80. doi: 10.4103/0973-7847.134229. PMID: 25125878; PMCID: PMC4127824.

- Herbal medicine [Internet]. Johns Hopkins Medicine. 2021 [cited 2022Oct12]. Available from: https://www.hopkinsmedicine.org/health/wellness-and-prevention/herbal-medicine

https://www.hopkinsmedicine.org/health/wellness-and-prevention/herbal-medicine

- Parasuraman S, Thing GS, Dhanaraj SA. Polyherbal formulation: Concept of ayurveda. Pharmacogn Rev. 2014 Jul;8(16):73-80. doi: 10.4103/0973-7847.134229. PMID: 25125878; PMCID: PMC4127824.

- Fu, J., Wang, Z., Huang, L., Zheng, S., Wang, D., Chen, S., … Yang, S. (2014). Review of the Botanical Characteristics, Phytochemistry, and Pharmacology of Astragalus membranaceus (Huangqi). Phytotherapy Research, 28(9), 1275–1283.doi:10.1002/ptr.5188

- Falzon CC, Balabanova A. Phytotherapy: An Introduction to Herbal Medicine. Prim Care. 2017 Jun;44(2):217-227. doi: 10.1016/j.pop.2017.02.001. PMID: 28501226.

- Block, K. I., & Mead, M. N. (2003). Immune System Effects of Echinacea, Ginseng, and Astragalus: A Review. Integrative Cancer Therapies, 2(3), 247–267.doi:10.1177/1534735403256419

- Aarland RC, Bañuelos-Hernández AE, Fragoso-Serrano M, Sierra-Palacios ED, Díaz de León-Sánchez F, Pérez-Flores LJ, Rivera-Cabrera F, Mendoza-Espinoza JA. Studies on phytochemical, antioxidant, anti-inflammatory, hypoglycaemic and antiproliferative activities of Echinacea purpurea and Echinacea angustifolia extracts. Pharm Biol. 2017 Dec;55(1):649-656. doi: 10.1080/13880209.2016.1265989. PMID: 27951745; PMCID: PMC6130640.

- Ross SM. Echinacea purpurea: A Proprietary Extract of Echinacea purpurea Is Shown to be Safe and Effective in the Prevention of the Common Cold. Holist Nurs Pract. 2016 Jan-Feb;30(1):54-7. doi: 10.1097/HNP.0000000000000130. PMID: 26633727.

- Sharifi-Rad M, Mnayer D, Morais-Braga MFB, Carneiro JNP, Bezerra CF, Coutinho HDM, Salehi B, Martorell M, Del Mar Contreras M, Soltani-Nejad A, Uribe YAH, Yousaf Z, Iriti M, Sharifi-Rad J. Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications. Phytother Res. 2018 Sep;32(9):1653-1663. doi: 10.1002/ptr.6101. Epub 2018 May 10. PMID: 29749084.

- Barrett B. Medicinal properties of Echinacea: a critical review. Phytomedicine. 2003 Jan;10(1):66-86. doi: 10.1078/094471103321648692. PMID: 12622467.

- Kumar D, Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V. A review of immunomodulators in the Indian traditional health care system. J Microbiol Immunol Infect. 2012 Jun;45(3):165-84. doi: 10.1016/j.jmii.2011.09.030. Epub 2011 Dec 11. PMID: 22154993.

- Xu, W., Choi, H.-K., & Huang, L. (2017). State of Panax ginseng Research: A Global Analysis. Molecules, 22(9), 1518.doi:10.3390/molecules22091518

- Fan, S., Zhang, Z., Su, H., Xu, P., Qi, H., Zhao, D., & Li, X. (2020). Panax ginseng clinical trials: Current status and future perspectives. Biomedicine & Pharmacotherapy, 132, 110832.doi:10.1016/j.biopha.2020.110832

- Kim JH. Pharmacological and medical applications of Panax ginseng and ginsenosides: a review for use in cardiovascular diseases. J Ginseng Res. 2018 Jul;42(3):264-269. doi: 10.1016/j.jgr.2017.10.004. Epub 2017 Oct 21. PMID: 29983607; PMCID: PMC6026386.

- Ong WY, Farooqui T, Koh HL, Farooqui AA, Ling EA. Protective effects of ginseng on neurological disorders. Front Aging Neurosci. 2015 Jul 16;7:129. doi: 10.3389/fnagi.2015.00129. PMID: 26236231; PMCID: PMC4503934.

- Gui QF, Xu ZR, Xu KY, Yang YM. The Efficacy of Ginseng-Related Therapies in Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-analysis. Medicine (Baltimore). 2016 Feb;95(6):e2584. doi: 10.1097/MD.0000000000002584. PMID: 26871778; PMCID: PMC4753873.

- Liu J, Nile SH, Xu G, Wang Y, Kai G. Systematic exploration of Astragalus membranaceus and Panax ginseng as immune regulators: Insights from the comparative biological and computational analysis. Phytomedicine. 2021 Jun;86:153077. doi: 10.1016/j.phymed.2019.153077. Epub 2019 Aug 23. Erratum in: Phytomedicine. 2021 Oct;91:153618. Erratum in: Phytomedicine. 2021 Oct;91:153730. PMID: 31477352.

- Mancuso C, Santangelo R. Panax ginseng and Panax quinquefolius: From pharmacology to toxicology. Food Chem Toxicol. 2017 Sep;107(Pt A):362-372. doi: 10.1016/j.fct.2017.07.019. Epub 2017 Jul 8. PMID: 28698154; PMCID: PMC7116968.

- Ogawa-Ochiai K, Kawasaki K. Panax ginsengfor Frailty-Related Disorders: A Review. Front Nutr. 2019 Jan 17;5:140. doi: 10.3389/fnut.2018.00140. PMID: 30705884; PMCID: PMC6344463.

- Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M, Sahebkar A. Immune modulation by curcumin: The role of interleukin-10. Crit Rev Food Sci Nutr. 2019;59(1):89-101. doi: 10.1080/10408398.2017.1358139. Epub 2017 Sep 6. PMID: 28799796.

- Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 2017 Sep 2;57(13):2889-2895. doi: 10.1080/10408398.2015.1077195. PMID: 26528921.

- Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 2017 Jun;174(11):1325-1348. doi: 10.1111/bph.13621. Epub 2016 Oct 21. PMID: 27638428; PMCID: PMC5429333.

- Kant V, Gopal A, Pathak NN, Kumar P, Tandan SK, Kumar D. Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats. Int Immunopharmacol. 2014 Jun;20(2):322-30. doi: 10.1016/j.intimp.2014.03.009. Epub 2014 Mar 24. PMID: 24675438.

- Ganjali S, Sahebkar A, Mahdipour E, Jamialahmadi K, Torabi S, Akhlaghi S, Ferns G, Parizadeh SM, Ghayour-Mobarhan M. Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial. ScientificWorldJournal. 2014 Feb 11;2014:898361. doi: 10.1155/2014/898361. PMID: 24678280; PMCID: PMC3942342.

- Sahebkar A. Dual effect of curcumin in preventing atherosclerosis: the potential role of pro-oxidant-antioxidant mechanisms. Nat Prod Res. 2015;29(6):491-2. doi: 10.1080/14786419.2014.956212. Epub 2014 Sep 5. PMID: 25190358.

- Panahi Y, Sahebkar A, Parvin S, Saadat A. A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications. Ann Clin Biochem. 2012 Nov;49(Pt 6):580-8. doi: 10.1258/acb.2012.012040. Epub 2012 Oct 4. PMID: 23038702.

- Momtazi AA, Shahabipour F, Khatibi S, Johnston TP, Pirro M, Sahebkar A. Curcumin as a MicroRNA Regulator in Cancer: A Review. Rev Physiol Biochem Pharmacol. 2016;171:1-38. doi: 10.1007/112_2016_3. PMID: 27457236.

- Momtazi AA, Derosa G, Maffioli P, Banach M, Sahebkar A. Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases. Mol Diagn Ther. 2016 Aug;20(4):335-45. doi: 10.1007/s40291-016-0202-7. PMID: 27241179.

- Esmaily H, Sahebkar A, Iranshahi M, Ganjali S, Mohammadi A, Ferns G, Ghayour-Mobarhan M. An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chin J Integr Med. 2015 May;21(5):332-8. doi: 10.1007/s11655-015-2160-z. Epub 2015 Mar 17. PMID: 25776839.

- Zhang J, Wu C, Gao L, Du G, Qin X. Astragaloside IV derived from Astragalus membranaceus: A research review on the pharmacological effects. Adv Pharmacol. 2020;87:89-112. doi: 10.1016/bs.apha.2019.08.002. Epub 2019 Dec 18. PMID: 32089240.

- Yang ZG, Sun HX, Fang WH. Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice. Vaccine. 2005 Oct 25;23(44):5196-203. doi: 10.1016/j.vaccine.2005.06.016. PMID: 16043270.

- Yu DH, Bao YM, An LJ, Yang M. Protection of PC12 cells against superoxide-induced damage by isoflavonoids from Astragalus mongholicus. Biomed Environ Sci. 2009 Feb;22(1):50-4. doi: 10.1016/S0895-3988(09)60022-2. PMID: 19462688.

- Qin Q, Niu J, Wang Z, Xu W, Qiao Z, Gu Y. Astragalus membranaceus inhibits inflammation via phospho-P38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB pathways in advanced glycation end product-stimulated macrophages. Int J Mol Sci. 2012;13(7):8379-8387. doi: 10.3390/ijms13078379. Epub 2012 Jul 5. PMID: 22942709; PMCID: PMC3430240.

- Shen HH, Wang K, Li W, Ying YH, Gao GX, Li XB, Huang HQ. Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibition. J Ethnopharmacol. 2008 Mar 5;116(2):363-9. doi: 10.1016/j.jep.2007.12.002. Epub 2007 Dec 8. PMID: 18226482.

- Zhu H, Zhang Y, Ye G, Li Z, Zhou P, Huang C. In vivo and in vitro antiviral activities of calycosin-7-O-beta-D-glucopyranoside against coxsackie virus B3. Biol Pharm Bull. 2009 Jan;32(1):68-73. doi: 10.1248/bpb.32.68. PMID: 19122283.

- Fu J, Wang Z, Huang L, Zheng S, Wang D, Chen S, Zhang H, Yang S. Review of the botanical characteristics, phytochemistry, and pharmacology of Astragalus membranaceus (Huangqi). Phytother Res. 2014 Sep;28(9):1275-83. doi: 10.1002/ptr.5188. Epub 2014 Aug 2. PMID: 25087616.

- Auyeung KK, Han QB, Ko JK. Astragalus membranaceus: A Review of its Protection Against Inflammation and Gastrointestinal Cancers. Am J Chin Med. 2016;44(1):1-22. doi: 10.1142/S0192415X16500014. PMID: 26916911.

- Yin X, Zhang Y, Wu H, Zhu X, Zheng X, Jiang S, Zhuo H, Shen J, Li L, Qiu J. Protective effects of Astragalus saponin I on early stage of diabetic nephropathy in rats. J Pharmacol Sci. 2004 Jun;95(2):256-66. doi: 10.1254/jphs.fp0030597. PMID: 15215651.

- Huang HL, Liu CT, Chou MC, Ko CH, Wang CK. Noni (Morinda citrifolia L.) Fruit Extracts Improve Colon Microflora and Exert Anti-Inflammatory Activities in Caco-2 Cells. J Med Food. 2015 Jun;18(6):663-76. doi: 10.1089/jmf.2014.3213. Epub 2015 Feb 4. PMID: 25651187.

- Su BN, Pawlus AD, Jung HA, Keller WJ, McLaughlin JL, Kinghorn AD. Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity. J Nat Prod. 2005 Apr;68(4):592-5. doi: 10.1021/np0495985. PMID: 15844957.

- West BJ, Su CX, Jensen CJ. Hepatotoxicity and subchronic toxicity tests of Morinda citrifolia (noni) fruit. J Toxicol Sci. 2009 Oct;34(5):581-5. doi: 10.2131/jts.34.581. PMID: 19797868.

- Hirazumi A, Furusawa E. An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity. Phytother Res. 1999 Aug;13(5):380-7. doi: 10.1002/(sici)1099-1573(199908/09)13:5<380::aid-ptr463>3.0.co;2-m. PMID: 10441776.

- Lim BO, Lee SH, Park DK, Choue RW. Effect of dietary pectin on the production of immunoglobulins and cytokines by mesenteric lymph node lymphocytes in mouse colitis induced with dextran sulfate sodium. Biosci Biotechnol Biochem. 2003 Aug;67(8):1706-12. doi: 10.1271/bbb.67.1706. PMID: 12951503.

- Badescu M, Badulescu O, Badescu L, Ciocoiu M. Effects of Sambucus nigra and Aronia melanocarpa extracts on immune system disorders within diabetes mellitus. Pharm Biol. 2015 Apr;53(4):533-9. doi: 10.3109/13880209.2014.931441. Epub 2014 Oct 20. PMID: 25327310.

- Vlachojannis JE, Cameron M, Chrubasik S. A systematic review on the sambuci fructus effect and efficacy profiles. Phytother Res. 2010 Jan;24(1):1-8. doi: 10.1002/ptr.2729. PMID: 19548290.

- Knudsen, B. F., & Kaack, K. V. (2015). A REVIEW OF HUMAN HEALTH AND DISEASE CLAIMS FOR ELDERBERRY (SAMBUCUS NIGRA) FRUIT. Acta Horticulturae, (1061), 121–131.doi:10.17660/actahortic.2015.

- Santin JR, Benvenutti L, Broering MF, Nunes R, Goldoni FC, Patel YBK, de Souza JA, Kopp MAT, de Souza P, da Silva RCV, Pastor MVD, de Souza AB, Testoni LD, Couto AG, Bresolin TMB, Quintão NLM. Sambucus nigra: A traditional medicine effective in reducing inflammation in mice. J Ethnopharmacol. 2022 Jan 30;283:114736. doi: 10.1016/j.jep.2021.114736. Epub 2021 Oct 11. PMID: 34648899.

- Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019 Feb;42:361-365. doi: 10.1016/j.ctim.2018.12.004. Epub 2018 Dec 18. PMID: 30670267.

- Singh G, Saxena R. 2017. Medicinal Properties of Tinospora Cordifolia (Guduchi). International J Adv Res. 3(6):227–231. Ideas and Innovations in Technology.

- Maurya, R., Wazir, V., Kapil, A., & Kapil, R. S. (1996). Cordifoliosides A and B, two New Phenylpropene Disaccharides fromTinospora cordifoliapossessing Immunostimulant Activity. Natural Product Letters, 8(1), 7–10.doi:10.1080/10575639608043231

- Ilaiyaraja N, Khanum F. 2011. Antioxidant Potential of Tinospora cordifolia Extracts and their Protective Effect on Oxidation of Biomolecules. Pharmacognosy J. 3(20):56–62. doi:10.5530/pj. 2011.20.11.

- Bonvicini F, Mandrone M, Antognoni F, Poli F, Gentilomi GA. Ethanolic extracts of Tinospora cordifolia and Alstonia scholaris show antimicrobial activity towards clinical isolates of methicillin-resistant and carbapenemase-producing bacteria. Nat Prod Res. 2014;28(18):1438-45. doi: 10.1080/14786419.2014.909421. Epub 2014 Apr 22. PMID: 24749692.

- Kavitha BT, Shruthi SD, Rai SP, Ramachandra YL. Phytochemical analysis and hepatoprotective properties of Tinospora cordifolia against carbon tetrachloride-induced hepatic damage in rats. J Basic Clin Pharm. 2011 Jun;2(3):139-42. Epub 2011 Aug 15. PMID: 24826014; PMCID: PMC3979222.

- Kosaraju J, Chinni S, Roy PD, Kannan E, Antony AS, Kumar MN. Neuroprotective effect of Tinospora cordifolia ethanol extract on 6-hydroxy dopamine induced Parkinsonism. Indian J Pharmacol. 2014 Mar-Apr;46(2):176-80. doi: 10.4103/0253-7613.129312. PMID: 24741189; PMCID: PMC3987186.

- Aranha I, Clement F, Venkatesh YP. Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi (Tinospora cordifolia). J Ethnopharmacol. 2012 Jan 31;139(2):366-72. doi: 10.1016/j.jep.2011.11.013. Epub 2011 Nov 20. PMID: 22119223.

- Yates CR, Bruno EJ, Yates MED. Tinospora Cordifolia: A review of its immunomodulatory properties. J Diet Suppl. 2022;19(2):271-285. doi: 10.1080/19390211.2021.1873214. Epub 2021 Jan 22. PMID: 33480818.

- Gibbons A. Archaeology. Ancient figs push back origin of plant cultivation. Science. 2006 Jun 2;312(5778):1292. doi: 10.1126/science.312.5778.1292a. PMID: 16741083.

- Yang XM, Yu W, Ou ZP, Ma HL, Liu WM, Ji XL. Antioxidant and immunity activity of water extract and crude polysaccharide from Ficus carica L. fruit. Plant Foods Hum Nutr. 2009 Jun;64(2):167-73. doi: 10.1007/s11130-009-0120-5. PMID: 19466553.

- Chen R, Li H, Li S, Jin C, Lu J. Extraction optimization, preliminary characterization and immunological activity of polysaccharides from figs. Int J Biol Macromol. 2015 Jan;72:185-94. doi: 10.1016/j.ijbiomac.2014.08.021. Epub 2014 Aug 23. PMID: 25159879.

- Du J , Li J , Zhu J , Huang C , Bi S , Song L , Hu X , Yu R . Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica. Food Funct. 2018 Jul 17;9(7):3930-3943. doi: 10.1039/c8fo00603b. PMID: 29974087.

- Zou Q , Zhang X , Liu X , Li Y , Tan Q , Dan Q , Yuan T , Liu X , Liu RH , Liu Z . Ficus carica polysaccharide attenuates DSS-induced ulcerative colitis in C57BL/6 mice. Food Funct. 2020 Jul 1;11(7):6666-6679. doi: 10.1039/d0fo01162b. Epub 2020 Jul 13. PMID: 32658237.

Artigos mais lidos pelo mesmo(s) autor(es)

1 2 > >>