COVID-19 Pathophysiology: Characteristics of the Immune Response of Children and Adults.
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ABSTRACT
Objective: to present the pathophysiology of COVID-19 and the main factors that differentiate the disease spectrum and immune response between the pediatric and adult age group. Literature review: Narrative bibliographic exploratory study conducted on the digital platforms PubMed, LILACS and Scielo, covering publications within the period from 2016 to 2021, having selected a sample of 18 articles that address aspects such as structure and interaction of the virus with humans as well as its replication, main differences on clinical characteristics of COVID-19 in children and adults and immune response. Conclusion: It was possible to elucidate the factors that interfere in the susceptibility of the disease by COVID-19 and in the different immune response between children and adults.
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References
World Health Organization. Coronavirus Disease (COVID-19). World Health Organization; 2020 [acesso 13 de maio 2021]. Disponível em: https://www.who.int/news-room/q-a-detail/coronavirus-disease-covid-19
Xu J, Ma XP, Bai L, Wang M, Deng W, Ning N. A systematic review of etiology, epidemiology, clinical manifestations, image findings, and medication of 2019 Corona Virus Disease-19 in Wuhan, China. Medicine. 2020; 99:(42):e22688.
Yesudhas D, Srivastava A, Gromiha MM. COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics. Infection. 2020;49(2):199-213.
World Health Organization. Coronavirus Disease 2019 (COVID-19) Situation Report – 51. WHO; 2020.
Uddin M, Mustafa F, Rizvi TA, Loney T, Suwaidi HA, Al-Marzouqi A, et al. SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions. Viruses. 2020;12(5):526.
Najm A, Alunno A, Mariette X, Terrier B, De Marco G, Emmel J, et al. Pathophysiology of acute respiratory syndrome coronavirus 2 infection: a systematic literature review to inform EULAR points to consider. RMD Open. 2021;7(1):e001549
Williams P, Howard-Jones AR, Hsu P, Palasanthiran P, Gray PE, McMullan BJ, et al. SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings. Pathology. 2020;52(7):801-808.
Lingappan K, Karmouty QH, Davies J, Akkanti B, Harting MT. Understanding the age divide in COVID-19: why are children overwhelmingly spared?. Am J Physiol Lung Cell Mol Physiol. 2020;319(1):L39–L44.
Umakanthan S, Sahu P, Ranade AV, Bukelo MM, Sushil Rao J, Abrahao-Machado LF, et al. Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19). Postgraduate Medical Journal. 2020;96:753-758.
Buonsenso D, Sali M, Pata D, De Rose C, Sanguinetti M, Valentini P, et al. Children and COVID-19: Microbiological and immunological insights. Pediatric Pulmonology. 2020;55(10):2547– 2555.
Wallentin L, Lindback J, Eriksson N, Hijazi Z, Eikelboom J, Ezekowitz M, et al. Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. Eur Heart J. 2020;41(41):4037-4046.
Rivellese F, Predilletto E. ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia. Autoimmune Rev. 2020;19(6):102536.
Li B, Zhang S, Zhang R, Chen X, Wang Y, Zhu C. Epidemiological and Clinical Characteristics of COVID-19 in Children: A Systematic Review and Meta-Analysis. Front Pediatr. 2020;8:591132.
Rabha AC, Junior FIDO, de Oliveira TA, Cesar RG, Fongaro G, Mariano RF, et al. Clinical Manifestations Of Children And Adolescents With Covid-19: Report Of The First 115 Cases From Sabará Hospital Infantil. Rev. paul. pediatr. 2021; 39:e2020305.
Palmeira P, Barbuto JAM, Clovis AAS, Magda CS. Why is SARS-CoV-2 infection milder among children?. Clinics. 2020;75:e1947.
Polat C e Ergunay K. Insights into the virologic and immunologic features of SARS-COV-2. World J Clin Cases. 2021;9(19): 5007–5018.
De Candia P, Prattichizzo F, Garavelli S, Matarese G. T Cells: Warriors of SARS-CoV-2 Infection. Trends Immunol. 2020;42(1):18–30.
Kim JS, Lee JY, Yang JW, Lee KH, Effenberger M, Szpirt W, et al. Immunopathogenesis and treatment of cytokine storm in COVID-19. Theranostics. 2021;11(1): 316–329.