Contributions of the intestinal microbiota to bone

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Rafael Pacheco da Costa
Carlos Rocha Oliveira
Adriana Gibotti


Introduction: Overall bone metabolism is highly regulated by the intestine, mainly mediated by parathyroid hormone (PTH) and vitamin D. However, emerging pieces of evidence have shown this regulation is also strongly associated with intestinal microbiota by releasing metabolites, which affects directly or indirectly the bone. Objective: To review the contributions of the intestinal microbiota to bone. Methods: Thus, a narrative review from articles on contributions of intestinal microbiota to bone was conducted using database PubMed covering a period from 1997 until July 2023. Articles published in the form of original articles, systematic review or meta-analysis using the descriptors: bone and microbiota, bone and bacteria, gut microbiota and bone and probiotics were read and summarized throughout text. Results: Initially, we searched for understanding, which bacteria are resident or transitory and which are the factors released that either indirectly or directly act on bone, thus modifying its quantity or quality. Therein, we briefly explored how intestine, and bone are interconnected and finally about how the type of intestinal microbiota is associated with bone metabolism, quality and quantity. In particular, we reported some main studies on probiotics and bone health. Conclusion: This review brought together information from the literature on the role of intestinal bacteria in bone, revealing possibilities for directing the microbiota to maintain or gain bone in quantity and quality and thus prevent bone fractures in a close future, especially for osteoporotic individuals.

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Pacheco da Costa R, Rocha Oliveira C, Gibotti A. Contributions of the intestinal microbiota to bone. Braz. J. Nat. Sci [Internet]. 23º de janeiro de 2024 [citado 24º de fevereiro de 2024];5(1):E195202 -, 1. Disponível em:
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Biografia do Autor

Rafael Pacheco da Costa, Western São Paulo University School of Medicine at Guarujá - UNOESTE

Western São Paulo University School of Medicine at Guarujá - UNOESTE

Carlos Rocha Oliveira, Anhembi Morumbi University School of Medicine São José dos Campos

Anhembi Morumbi University School of Medicine São José dos Campos

Adriana Gibotti, Western São Paulo University School of Medicine at Guarujá - UNOESTE

Western São Paulo University School of Medicine at Guarujá - UNOESTE


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