Synergistic Effect of Baccharis dracunculifolia DC and Green Propolis with Antimicrobial Drugs against Staphylococcus aureus

Conteúdo do artigo principal

Rogerio da Silva Veiga
Maria Cristina Marcucci
Carmen Lucia Queiroga
Alexandra Christine Helena Frankland Sawaya
Cely Barreto da Silva
Suzethe Matiko Sasagawa
Alessandra Navarini
Giulia Marchetti
Gabriela Tomaz Martinho
Erika Tiemi Fukunaga
Carolina Passarelli Gonçalves
Marcelo Jenne Mimica

Resumo

Abstract: Relevance: This study demonstrated the synergism of various natural preparations in combination with antibiotics, which is a matter of high potential therapeutic interest due to the de- velopment of bacterial resistance to these antibiotic drugs. This synergism is very relevant because it demonstrates that these extracts and their association with these antibiotics may be viable thera- peutic options against the pathogens that are responsible for a high incidence of nosocomial and community infections. Aims: The study investigated the antibacterial activity against Staphylococcus aureus isolates (methicilin-sensitive Staphylococcus aureus (MSSA) and methicilin-resistant Staphylo- coccus aureus (MRSA)) of green propolis and Baccharis dracunculifolia DC. ethanolic extracts com- bined with classical antibiotics. Methods and Results: In the test of the antibacterial activity of the combination of classical antibiotics with natural extracts (ten antibiotics plus one association of two antimicrobial disc diffusions), 25 isolates were used. The isolates were inoculated in Müeller–Hinton agar culture medium containing the green propolis and Baccharis dracunculifolia DC. extracts. Bac- charis dracunculifolia DC ethanolic extract (BDEE) showed higher antibacterial synergistic behavior with the antibiotics tested than green propolis ethanolic extract (PVEE). Conclusions: BDEE was the preparation that showed the best synergistic antimicrobial effect in sub-doses with the tested anti- biotics. These activities may be related to Artepillin C, the major compound in PVEE, and nerolidol, the major compound in BDEE, in synergism with other minority compounds and related antibiotics.

Detalhes do artigo

Como Citar
1.
da Silva Veiga R, Cristina Marcucci M, Lucia Queiroga C, Helena Frankland Sawaya AC, Barreto da Silva C, Matiko Sasagawa S, Navarini A, Marchetti G, Tomaz Martinho G, Tiemi Fukunaga E, Passarelli Gonçalves C, Jenne Mimica M. Synergistic Effect of Baccharis dracunculifolia DC and Green Propolis with Antimicrobial Drugs against Staphylococcus aureus. Braz. J. Nat. Sci [Internet]. 7º de agosto de 2023 [citado 24º de fevereiro de 2024];5(1):E1782023 - 1. Disponível em: https://bjns.com.br/index.php/BJNS/article/view/178
Seção
Artigo em fluxo contínuo
Biografia do Autor

Rogerio da Silva Veiga , Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo Brazil.

Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo Brazil.

Maria Cristina Marcucci, Pharmacy Department, Anhanguera University of São Paulo, Osasco, Sao Paulo, Brazil.

Pharmacy Department, Anhanguera University of São Paulo, Osasco, Sao Paulo, Brazil.

Carmen Lucia Queiroga ,  State University of Campinas, Pluridisciplinary Centre for Chemical, Biological and Agricultural Research (CPQBA), Campinas, Sao Paulo, Brazil.

 State University of Campinas, Pluridisciplinary Centre for Chemical, Biological and Agricultural Research (CPQBA), Campinas, Sao Paulo, Brazil.

 

 

Alexandra Christine Helena Frankland Sawaya, Faculty of Pharmaceutical Sciences, State University of Campinas, Campinas, Sao Paulo, Brazil.

Faculty of Pharmaceutical Sciences, State University of Campinas, Campinas, Sao Paulo, Brazil.

Cely Barreto da Silva,  Hospital Infection Control of Hospital Irmandade de Misericordia da Santa Casa de Sao Paulo, Brazil.

 Hospital Infection Control of Hospital Irmandade de Misericordia da Santa Casa de Sao Paulo,
Brazil.

 

 

Suzethe Matiko Sasagawa, Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

Alessandra Navarini,  Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

 Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

 

 

 

Giulia Marchetti, Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

Gabriela Tomaz Martinho, Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

 Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

Erika Tiemi Fukunaga, Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

Carolina Passarelli Gonçalves, Pharmacy Department, Anhanguera University of São Paulo, Osasco, Sao Paulo, 06020-015, Brazil.

 Pharmacy Department, Anhanguera University of São Paulo, Osasco, Sao Paulo, 06020-015, Brazil.

Marcelo Jenne Mimica, Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

Faculty of Medical Sciences of Santa Casa de São Paulo, Sao Paulo, Brazil.

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