Notch receptors as a therapeutic target in melanoma: a narrative bibliographic review

Conteúdo do artigo principal

Renato Santos de Oliveira Filho
Guilherme Routh Peixoto
Lorena Dal Collina Sangiuliano
Daniel Arcuschin de Oliveira

Resumo

O melanoma é o câncer de pele com maior mortalidade e mais e mais casos surgem a cada ano. A superexpressão de elementos da via de sinalização Notch já foi encontrada em linhagens de melanoma primário e metastático e está diretamente correlacionada ao desenvolvimento, crescimento, angiogênese, metástase e resistência ao tratamento do melanoma. Assim, a manipulação de Notch apresenta alto potencial terapêutico. A presente revisão teve como objetivo realizar uma revisão sobre os possíveis tratamentos do melanoma pela inibição da via de sinalização Notch. Pesquisamos a literatura existente sobre os inibidores da via de sinalização Notch em melanoma cutâneo humano, publicada entre 2000 e 2020, usando as bases de dados MEDLINE (via PubMed), LILACS (via Virtual Health Library) e Cochrane Library. Os artigos selecionados foram analisados, resumidos, tabelados e utilizados para a produção da presente revisão narrativa. Nos 24 artigos selecionados e em artigos referenciados neles, apresentaram-se como terapias os inibidores de γ-secretase (GSIs), principalmente, mas também gliotoxina, honokiol, fosfolipase A2, andrografolide e anticorpos monoclonais, que, entretanto, não foram estudados diretamente no melanoma. Outra terapia que interfere indiretamente na via de sinalização Notch e foi encontrada nesses artigos foram os inibidores de G9a. Com a revisão foi possível concluir que GSIs provavelmente não são a melhor opção para o tratamento do melanoma, excedendo cenários específicos ou pelo seu uso concomitante com outros inibidores de vias. Já o uso dos demais compostos tem maior potencial, porém mais estudos são necessários para comprovar sua eficácia e viabilidade para o tratamento do melanoma cutâneo humano.  


Palavras-chave: Melanoma;  inibidores; Receptores Notch

Detalhes do artigo

Como Citar
1.
Santos de Oliveira Filho R, Routh Peixoto G, Dal Collina Sangiuliano L, Arcuschin de Oliveira D. Notch receptors as a therapeutic target in melanoma: a narrative bibliographic review. Braz. J. Nat. Sci [Internet]. 3º de abril de 2021 [citado 24º de setembro de 2021];4(1):614 - 628. Disponível em: https://bjns.com.br/index.php/BJNS/article/view/138
Seção
ARTIGOS EM FLUXO CONTÍNUO - ISSN 2595-0584

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