Influence of environmental pollutants on the incidence of Atopic Dermatitis and possible dermatological assets for the development of anti-pollution dermocosmetics

Abstract

Atopic Dermatitis is a chronic inflammatory disease located in the cutaneous tissue and possesses its higher incidence observed in the first phase of childhood. One of the factors for the onset of the disease is genetic predisposition and external stimuli. Atopic Dermatitis has no specific action mechanism, but it is observed that intrinsic and extrinsic factors can stimulate its onset. The intrinsic factors are related to the genetic predisposition and how the organism reacts to different endogenous stimuli. External factors such as pollutant agents perform with high power to develop or cause escalation of Atopic Dermatitis because the skin’s exposure to stimuli and environmental pollutants end up causing the imbalance between oxidants and antioxidants and this imbalance causes oxidative stress that, eventually, generates the worsening of symptoms. Air pollution causes damage to lipids, proteins, and DNA detrimental. Thus, it is possible to relate Atopic Dermatitis to pollution and its particles. Therefore, it is possible to suggest the use of dermatological ingredients, in association to antipollution ingredients, in formulations to the disease at stake. Those ingredients have different origins and their properties can be directed for topical use in skin.