Oxidative stress and its impact on aging: a literature review
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Abstract
Life expectancy increased reflects in aging population, and consequently in an increase in diseases associated with it. Recent years have seen an increase of studies about this subject and this caused the development of many theories to explain this process among them is the Free Radicals Theory, now widely accepted. This theory defends the hypothesis that during normal aerobic metabolism, oxygen undergoes education to form reactive oxygen species, which would be added to other free radicals arising from different generating mechanisms. The body to defend itself against the damaging action of free radicals, has different antioxidant defense systems. The imbalance occurs in the formation of free radicals and in this process, there is na increase of the number of these reactive species, stage known as oxidative stress. In these cases, there would be a gradual loss of functional capacity of the cell, resulting in aging. However, definitive conclusions about the origin and development of aging require further studies, since this phenomenon may not have a fundamental cause.
Keywords: oxidative stress; aging; senescence; Oxigen-reactive species.
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References
SADOWSKA-BARTOSZ I., BARTOSZ G. Effect of Antioxidants Supplementation on Aging and Longevity. Hindawi Publishing Corporation BioMed Research International, Article ID 404680, pg 1-17, 2014.
TEIXEIRA J., FEIO M., FIGUEIRA M.L. O Papel do Stress Oxidativo no Envelhecimento e na Demência. Revista do Serviço de Psiquiatria do Hospital Professor Doutor Fernando Fonseca, EPE, vol. 12, nº 1, pg. 1-15, 2014.
LEITE L.M.G.S., BRASIL R.L.F; MARQUES T.M.A.; CRUZ J.B.; CATÃO C.D.S.; Estresse Oxidativo e Envelhecimento Humano: Uma Revisão Sistemática. Anais CIEH, vol. 2, n.1. ISSN 2318-0854, 2015.
GOTTLIEB M. G. V., MORASSUTTI A. L., CRUZ I. B. M. Transição epidemiológica, estresse oxidativo e doenças crônicas não transmissíveis sob uma perspectiva evolutiva. Scientia Medica. Porto Alegre, volume 21, número 2, p. 69- 80, 2011.
THAPA A. AND CARROLL N. J. Dietary Modulation of Oxidative Stress in Alzheimer’s Disease. International Journal of Molecular Sciences, pg. 1-14, 2017.
RICHARD F. LOESER, MD. The Role of Aging in The Development Of Osteoarthritis. Transactions of The American Clinical and Climatological Association, vol. 128, pg. 1-11, 2017.
SANTOS Z. A. Envelhecimento: a influência do exercício físico nas alterações moleculares associadas ao stress oxidativo em mulheres. Vila real, Universidade De Tras-Os-Montes e Alto Douro, 2014.
SKIBSKA B. and GORACA A. The Protective Effect of Lipoic Acid on Selected Cardiovascular Diseases Caused by Age-Related Oxidative Stress. Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity, Article ID 313021, pg 1-11, 2015.
JUNZHEN WE, SHIJIN XIA, BILL KALIONIS, WENBIN WAN, and TAO SUN.;The Role of Oxidative Stress and Inflammation in Cardiovascular Aging. Hindawi Publishing Corporation BioMed Research International, Article ID 615312, pg. 1-13, 2014.
MIRELLI PAPALIA DOS SANTOS. O papel das vitaminas antioxidantes na prevenção do envelhecimento cutâneo. UNIJUÍ, 2013.
DORIA E., BUONOCORE D., FOCARELLI A., and MARZATICO F. Relationship between Human AgingMuscle and Oxidative System Pathway. Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity, Article ID 830257, pg. 1-13, 2012.
BLASIAK J., PIECHOTA M., PAWLOWSKA E., SZATKOWSKA M., SIKORA E., and KAARNIRANTA K. Cellular Senescence inAge-Related Macul.
PASCUAL-AHUIR A., MANZANARES-ESTREDER S., and PROFT M. Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease. Hindawi Oxidative Medicine and Cellular Longevity, Article ID 9860841, pg. 1-17, 2017.
CHANDRASEKARAN A., IDELCHIK M. D. P. S., MELENDEZ A. J. Redox; control of senescence and age-related disease. Redox Biology, vol. 11, pg. 1-12, 2017.