Traditional Chinese Herbal Medicine and Corticosteroids in Asthma: A short review.

Conteúdo do artigo principal

Gustavo Carrião Santos
Eduardo Eler
Maria Eduarda Honorato
Nathalia Rocha
Paula Lobo Guimarães
Rafaela Curiele
Carlos Rocha Olliveira


Asthma is a prevalent chronic inflammatory disease that has gold standard treatment with corticosteroids, but these are associated with important long-term side effects. On this basis, Traditional Chinese Medicine contributes with therapeutic techniques such as the herbal Anti-Asthma Herbal Medicine Intervention (ASHMI). In this context, this study aims to evaluate the effectiveness of treatment with ASHMI compared to conventional therapy, considering the need for new therapeutic approaches. An integrative review was performed, according to the PRISMA methodology. Articles published between 2011 and 2021 that related Herbal Medicines of Traditional Chinese Medicine, asthma and corticosteroids were examined. The searches took place in October and November 2021 in the Scopus, PubMed, Web of Science, Google Scholar, and Scielo databases. The selection comprised steps such as: search, pre-selection and inclusion of articles. The results of the herbal medicine and its isolated components were demonstrated, with three studies being clinical trials with humans and four pre-clinical studies. From the results, the efficacy of the herbal medicine and its components compared to corticosteroids were evaluated. It was reported that ASHMI, unlike corticosteroids, does not suppress the hypothalamic-pituitary-adrenal axis and the immune system, having mild adverse effects




Detalhes do artigo

Como Citar
Santos GC, Eler E, Honorato ME, Rocha N, Guimarães PL, Curiele R, Rocha Olliveira C. Traditional Chinese Herbal Medicine and Corticosteroids in Asthma: A short review. Braz. J. Nat. Sci [Internet]. 17º de março de 2022 [citado 4º de março de 2024];4(3):E1522022, 1 - 6. Disponível em:
Artigo de revisão em fluxo contínuo


- World Health Organization. Asma. Acess in 29 oct 2021. Available in

- Leonard P, Sur S. Asthma: future directions. Med Clin North Am. 2002 Sep;86(5):1131-56. Acess in 29 oct 2021. Available in

- Heffler E, Madeira LNG, Ferrando M, Puggioni F, Racca F, Malvezzi L, Passalacqua G, Canonica GW. Inhaled Corticosteroids Safety and Adverse Effects in Patients with Asthma. J Allergy Clin Immunol Pract. 2018 May-Jun;6(3):776-781. Acess in 29 oct 2021. Available in

- Meneses AS. Chinese Herbal Medicine. [Dissertation]. Porto: UFP; 2016.

- Hong ML, Song Y, Li XM. Effects and mechanisms of actions of Chinese herbal medicines for asthma. Chin J Integr Med. 2011 Jul;17(7):483-91. Acess in 15 oct 2021. Available in

- Kelly-Pieper K, Patil SP, Busse P, Yang N, Sampson H, Li XM, Wisnivesky JP, Kattan M. Safety and tolerability of an antiasthma herbal Formula (ASHMI) in adult subjects with asthma: a randomized, double-blinded, placebo-controlled, dose-escalation phase I study. J Altern Complement Med. 2009 Jul;15(7):735-43. Acess in 15 oct 2021. Available in

- Wen MC, Wei CH, Hu ZQ, Srivastava K, Ko J, Xi ST, Mu DZ, Du JB, Li GH, Wallenstein S, Sampson H, Kattan M, Li XM. Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. J Allergy Clin Immunol. 2005 Sep;116(3):517-24. Acess in 15 oct 2021. Available in

-Jayaprakasam B, Yang N, Wen MC, Wang R, Goldfarb J, Sampson H, Li XM. Constituents of the anti-asthma herbal formula ASHMI(TM) synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells, and eotaxin by human lung fibroblasts in vitro. J Integr Med. 2013 May;11(3):195-205. Acess in 15 oct 2021. Available in

- Srivastava KD, Dunkin D, Liu C, Yang N, Miller RL, Sampson HA, Li XM. Effect of Antiasthma Simplified Herbal Medicine Intervention on neutrophil predominant airway inflammation in a ragweed sensitized murine asthma model. Ann Allergy Asthma Immunol. 2014 Apr;112(4):339-47.e1-2. Acess in 15 oct 2021. Available in

- Hoang BX, Shaw DG, Levine S, Hoang C, Pham P. New approach in asthma treatment using excitatory modulator. Phytother Res. 2007 Jun;21(6):554-7. Acess in 15 oct 2021. Available in

- Hong MH, Lee JY, Jung H, Jin DH, Go HY, Kim JH, Jang BH, Shin YC, Ko SG. Sophora flavescens Aiton inhibits the production of pro-inflammatory cytokines through inhibition of the NF kappaB/IkappaB signal pathway in human mast cell line (HMC-1). Toxicol In Vitro. 2009 Mar;23(2):251-8. Acess in 15 oct 2021. Available in

- Liu F, Xuan NX, Ying SM, Li W, Chen ZH, Shen HH. Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications. Mediators Inflamm. 2016;2016:6943135. Acess in 15 oct 2021. Available in

- Liu C, Yang N, Song Y, Wang L, Zi J, Zhang S, Dunkin D, Busse P, Weir D, Tversky J, Miller RL, Goldfarb J, Zhan J, Li XM. Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients. Int Immunopharmacol. 2015 Aug;27(2):224-31. Acess in 15 oct 2021. Available in

- Zhang Y, Wang X, Zhang H, Tang H, Hu H, Wang S, Wong VKW, Li Y, Deng J. Autophagy Modulators From Chinese Herbal Medicines: Mechanisms and Therapeutic Potentials for Asthma. Front Pharmacol. 2021 Jul 23;12:710679. Acess in 15 oct 2021. Available in

Maria Pia GD, Sara F, Mario F, Lorenza S. Biological Effects of Licochalcones. Mini Rev Med Chem. 2019;19(8):647-656. doi: 10.2174/1389557518666180601095420. PMID: 30049263.

Yang R, Yuan BC, Ma YS, Zhou S, Liu Y. The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharm Biol. 2017 Dec;55(1):5-18. doi: 10.1080/13880209.2016.1225775. Epub 2016 Sep 21. PMID: 27650551; PMCID: PMC7012004.