Melaleuca spp. essential oil and its medical applicability. A Brief Review
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Oliveira T, Teixeira A, Barbosa J, Busato de Feiria S, Boni G, Maia F, Anibal P, Wijesinghe G, Höfling J. Melaleuca spp. essential oil and its medical applicability. A Brief Review. bjns [Internet]. 11mar.2020 [citado 10abr.2020];3(1):249. Available from: http://bjns.com.br/index.php/BJNS/article/view/89

Resumo

Plantas medicinais há muito vêm sendo empregadas, como alternativa no tratamento de doenças, quer pelo uso de extratos, de óleos essenciais e/ ou respectivos componentes bioativos. De tal forma, a utilização de plantas medicinais, com efeitos popularmente conhecidos para tratamento de infecções, ganhou destaque, em pesquisas envolvendo extratos e óleos essenciais de plantas medicinais, na tentativa da descoberta e, futura aplicação, de novas moléculas com efeito antimicrobiano e/ou moléculas coadjuvantes aos antimicrobianos existentes no mercado. Estudos com as espécies de Melaleuca spp., têm demonstrado ampla aplicabilidade de seu óleo essencial, no tratamento de infecções de pele, infecções microbianas, herpes, inclusive doenças associadas a microrganismos patogênicos da cavidade oral. A emergente resistência microbiana aos fármacos disponíveis atualmente no mercado, tem preocupado tanto aos pesquisadores, quanto a população em geral, de tal forma, que as atuais pesquisas têm sido conduzidas revelando um elevado potencial sinérgico entre os fármacos e compostos naturais, presentes em óleos essenciais. Diante do exposto, este trabalho teve por objetivo apresentar, por meio de levantamento bibliográfico, a utilização de plantas medicinais frente a resistência microbiana, bem como a terapêutica medicinal a partir do uso dos óleos essenciais de Melaleuca alternifolia, Melaleuca leucadendron e Melaleuca quinquenervia, já descritos na literatura.

https://doi.org/10.31415/bjns.v3i1.89
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1. Abrantes M.R.; Lima E.O.; Medeiros M.A.P.; Menezes C.P.; Guerra, F.Q.S.; Milan E.P. Antifungal activity of essential oils on non Candida albicans yeasts. Rev. Bras. Farm. 94 (3): 227 – 233, 2013
2. Al-Mariri A, Safi M. The antibacterial activity of selected Labiatae (Lamiaceae) essencial oil against Brucella melitensis. Iran J Med Sci, 2013; v.38, n.1, p. 44-50.
3. Alvarenga AL, Schwan RF, DRD, Schwan-Estrada KRF, Bravo-Martins CEC. Atividade antimicrobiana de extratos vegetais sobre bactérias patogênicas humanas. Rev Bras Pl Med. 2007; 9:86–91.
4. Amri I, Mancini E, De Martino L, Marandino A, Lamia H, Molshen H, Bossen Y, Scognanidio M, Reveichan E, De Feo V. Chemical composition and biological activities of the essential oil, from tree Melaleuca species grown in Tunisia. Int J Mol Sci 2012 Dec; 13(12): 16580-91.
5. Bagg, A. J.; Jackson M. S.; Sweeney M. P.; Ramag G.; Davies A. N. 2006 - Susceptibility to Melaleuca alternifolia (tea tree) oil of yeasts isolated from the mouths of patients with advanced cancer. Oral Oncology, v. 42, p. 487-492.
6. Banes-Marshall, L.; Cawley, P.; Phillips, C.A. In vitro activity of Melaleuca alternifolia (tea tree) oil against bacterial and Candida spp. isolates from clinical specimens. British Journal of Biomedical Science, 2001, v.58, p.139-145,
7. Barbosa, J P. Atividade anti-Candida de óleos essenciais de espécies de Eucalyptus. 2018. 1 recurso online (73 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Piracicaba, SP.
8. Barbosa, JP; Oliveira, TR; Puppin, DGPB, Teixeira, A L, Boni, GC; et al.; Eucalyptus spp: Candida albicans Antibiofilm Activity. EC Dental Science 18.5 (2019): 824-840.
9. Benger, S.; Townsend, P.; Ashford, R.L.; Lambert, P. An in vitro study to determine the minimum inhibitory concentration of Melaleuca alternifolia against the dermatophyte Trichophyton rubrum. The Foot, v.14, p.86-91, 2004. doi: 10.1016/j.foot.2003.11.002
10. Blake, S.T. 1968. A revision of Melaleuca leucadendron and its allies (Myrtaceae). Contributions from the Queensland Herbarium, v. 1, p. 1–114
11. Blumenthal, M.; Busse, W.R.; Goldberg, A.; Gruenwald, J.; Hall, T.; Riggins, C.W. e Rister, R.S. (eds.) - The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. 1998, 1st edition. Boston, MA: American Botanical Council. p. 684 DOI: 10.4236/ad.2016.41004.
12. Boland, D.J., Brooker M.I.H., Chippendale G.M., Hall N., Hyland B.P.M., Johnston R.D., Kleinig D.A., and Turner J.D. 1984. Forest trees of Australia, 4th ed. Thomas Wadsworth, Melbourne, Australia.
13. Brophy JJ, Davies NW, Southwell IA, Stiff IA, Williams LR. Gas chromatographic quality control for oil of Melaleuca terpin-4-ol type (Australian tea tree). J.Agric. Food Chem, 1998; 37:1330-1335.
14. Brophy, J.J. et al. Gas chromatographic quality control for oil of Melaleuca terpinen-4-ol type (Australian tea tree). Journal of Agriculture and Food Chemistry, 1989.v.37, p.1330- 5.
15. Brophy, J.J.; Davies, N.W.; Southwell, I.A.; Stiff, I.A.; Williams, L.R. - Gas chromatographicquality control for oil of Melaleuca terpinen-4-ol type (Australian tea tree). Journal of Agricultural and Food Chemistry, 1989, v. 37, p. 1330-5.
16. Buck, D.S.; Nidorf, D.M.; Addino, J.G. Comparison of two topical preparations for the treatment of onychomycosis: Melaleuca alternifolia (tea tree) oil and clotrimazole.The Journal of Family Practice, v. 38, p. 601-605, 1994.
17. Budhiraja, S.S.; Cullum, M.E.; Sioutis, S.S.; Evangelista, L.; Habanova, S.T. - Biological activity of Melaleuca alternifolia (Tea Tree) oil component, terpenin-4-ol, in human myelocytic cell line HL-60. Journal of Manipulative and Physiological Therapeutics, v. 22, p. 447-453. 1999.
18. Buso-Ramos, M M. Atividade anticandida e citotoxicidade do óleo essencial de Psidium cattleyanum (araçá-amarelo). 2017. 1 recurso online (77 p.). Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Piracicaba, SP.
19. Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties. Clin Microbiol Rev. 2006 Jan; 19 (1): 50–62.
20. Carson, C.F.; Riley, T.V. - Antimicrobial activity of the essential oil of Melaleuca alternifolia. Letters in Applied Microbiology, 1993 v. 16, p. 49-55.
21. Carson, C.F.; Riley, T.V. - The antimicrobial activity of the tea tree oil. Medical Journal of Australia, 1994, v. 160, p. 236.
22. Carson, C.F.; Riley, T.V. 1995 - Antimicrobial activity of the major components of the essential oil of Melaleuca alternifolia. Journal of Applied Bacteriology, v. 78, p. 264-269.
23. Carson, C.F.; Riley, T.V.; Cookson, B.D. Efficacy and safety of tea tree oil as a topical antimicrobial agent. Journal of Hospital Infection, v. 40, p. 175-178, 1998
24. Casarin, M; Pazinatto, J; Santos, R C V; Zanatta, F B. Melaleuca alternifolia and its application against dental plaque and periodontal diseases: A systematic review. Phytother Res, 32(2):230-242, Feb. 2018.
25. Castro R.D.; Lima E.O (2010) Atividade antifungica in vitro de óleo essencial de Eucalyptus glóbulos L. sobre Candida spp. Revista de Odontologia da UNESP, v.39, n.3, p. 179-184
26. Cecanho R, Koo H, Rosalen PLJA, Park YK, Cury JA. Efeito do extrato hidroetanólico de Mikania laevigata sobre o crescimento bacteriano e a produção de glucamos por estreptococcus do grupo mutans. Anais da XIV Reunião Anual da FESBE, Caxambu - MG, 1999; 14: 290.
27. Cechinel Filho V, Yunes RA. Estrategies for obtaining pharmacologically active compounds from medicinal plants: concepts about structural modification for improve the activity. Quím Nova. 1998 Feb;21(1):99–105.
28. Craven, L. A. 1999 - Behind the names: the botany of tea tree, cajuput and niaouli. In: Southwell, I.A.; Lowe, R.F. (ed.). Tea Tree: The Genus Melaleuca, p. 11-28. Series Medicinal and Aromatic Plants, Industrial Profiles, vol. 9. Amsterdam: Harwood Academic Publishers.
29. Craven, L.A.; Dawson, J.W. - Callistemon of New Caledonia transferred to Melaleuca (Myrtaceae). Adansonia, v. 20, p. 191–194. 1998
30. D’Arrigo, M.; Ginestra, G.; Mandalari, G.; Furneri, P.M.; Bisignano, G. 2010 - Synergism and postantibiotic effect of tobramycinand Melaleuca alternifolia (tea tree) oil against Staphylococcus aureus and Escherichia coli. Phytomedicine, v. 17, p. 317-322
31. Doran, J. C., and J. W. Turnbull. 1997. Australian trees and shrubs: species for land rehabilitation and farm planting in the tropics. Australian Centre for International Agricultural Research, Canberra, Australia.
32. Doran, J. C.; Turnbull, J. W. Australian trees and shrubs: species for land rehabilitation and farm planting in the tropics. Canberra: Australian Centre for International Agricultural Research, 1997. 384 p.
33. Dray Jr., F.A. et al. Genetic variation in melaleuca quinquenervia affects the biocontrol agent oxyops vitiosa. Weed Technol., v. 18, n. 1, p. 1400-1402, 2004.
34. Duarte MCT, Figueira GM, Pereira B, Magalhães PM, Delarmina C. Atividade antimicrobiana de extratos hidroalcoólicos de espécies da coleção de plantas medicinais CPQBA/UNICAMP.Rev. Bras. Farmacogn,2004; 14(01): 06-08.
35. Falci SPP et al. Antimicrobial activity of Melaleuca sp. oil against clinical isolates of antibiotics resistant Staphylococcus aureus. Acta Cirurgica Brasileira, v. 30, n. 6, p. 401-406, 2015.
36. Fenner, R.; Betti, A.H.; Mentz, L.A.; Rates, S.M.K. 2006 - Plantas utilizadas na medicina popular brasileira com potencial atividade antifúngica. Revista Brasileira de Ciências Farmacêuticas, v. 42, n. 3, p. 369-394.
37. Finlay-Jones, J.; Hart, P.; Riley, T. et al. Anti-inflammatory activity of tea tree oil. Nedlands, Australia: Rural Industries Research and Development Corporation, 2001.
38. Garozzo, A.; Timpanaro, R.; Stivala, A.; Bisignano, G.; Castro, A. - Activity of Melaleuca alternifolia (tea tree) oil on Influenza virus A/PR/8: Study on the mechanism of action. Antiviral Research, 2011, v. 89, p. 83-88.
39. Gonçalves, B.; Ferreira, C.; Alves, C.T.; Henriques, M.; Azeredo, J.; Silva, S. Vulvovaginal candidiasis: epidemiology, microbiology and risk factors. Critical Reviews in Microbiology, v. 42, n. 6, p. 905-927, 2016.
40. Graziano, T S; Calil, C M; Sartoratto, A; Franco, GC N; Groppo, F C; Cogo-Müller, K. In vitro effects of Melaleuca alternifolia essential oil on growth and production of volatil e sulphurcompounds by oral bacteria.J Appl Oral Sci,24(6):582-589, Nov-Dec. 2016.
41. Groppo, F.C.; Ramacciato, J.C.; Simões, R.P. et al. Antimicrobial activity of garlic, tea tree oil, and chlorhexidine against oral microorganisms. International Dental Journal, v. 52, p. 433-437, 2002
42. Gruenwald, J.; Brendler, T. e Jaenicke, C. 2000 - PDR® for Herbal MedicinesTM. Montvale, NJ: Medical Economics Company Inc. 858 p
43. Halcón L.; Milkus, K. Staphylococcus aureus and wounds: A review of tea tree oil as a promising antimicrobial. American Journal of Infection Control, v. 32, n. 7, 2004
44. Hammer, K.A.; Carson, C.F.; RileY, T.V. In vitro susceptibility of Malassezia furfur to the essential oil of Melaleuca alternifolia Journal of Medical and Veterinary Mycology, v. 35, p. 375-377, 1997
45. Hammer, K.A.; Carson, C.F.; Riley, T.V. Susceptib ility of transient and commensal skin flora to the essential oil of Melaleuca alternifolia (tea tree oil). American Journal of Infection Control, v. 24, p. 186-189, 1996.
46. Hammer, K.L.; Carson, C.F.; Riley, T.V. 1999 - Antimicrobial activity essencial oils and other plant extracts. Journal of Applied Microbiology, v. 86, p.985-990
47. Hart, P.H.; Brand, C.; Carson, C.F. et al.Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil) suppresses inflammatory mediator production by activated human monocytes. Inflammation Research, v.49, p.619-26, 2000.
48. Höfling. JF, et al. “Susceptibility Profile of the Essential Oil from E. muticus against C. albicans Biofilm”. EC Dental Science 18.8 (2019): 1844-1857.
49. Ireland F; Hibbert, D.B., Goldsack R.J, Doran J.C, Brophy J.J. Chemical variation in the leaf essential oil of Melaleuca quinquenervia (Cav.) S.T. Blake Biochemical Systematics and Ecology, 30 (2002), pp. 457-470
50. Jandourek, A.; Vaishampayan, J.K.; Vazquez, J.A. Efficacy of Melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. AIDS, v. 12, p. 1033-1037, 1998
51. Johns, M.R.; Johns, J.E.; Rudolph, V. 1992 - Steam distillation of tea tree (Melaleuca alternifolia) oil. Journal of the Science of Food and Agriculture, v. 58, p. 49-53
52. Karen B. Chin and Barbara Cordell.The Journal of Alternative and Complementary Medicine. 2013; v. 19; p. 942-945.http://doi.org/10.1089/acm.2012.0787.
53. Kaufman, S. R.; Smouse, P. E. Comparing indigenous and introduced populations of Melaleuca quinquenervia (Cav.) Blake: response of seedlings to water and pH levels. Oecologia, v. 127, n. 3, p. 487-494, 2001.
54. Khan SMA, Malik A, Ahmad I. Anti-Candidal activity of essential oils alone and in combination with amphotericin B or fluconazole against multi-drug resistant isolates of Candida albicans. Medical Mycology. 2012, 50:33–42
55. Leach, D.N.; Wyllie, S.G.; Hall, J.G.; Kyratzis, I. - Enantiomeric composition of the principal components of the oil of Melaleuca alternifolia. Journal of Agricultural and Food Chemistry, 1993, v. 41, p. 627-32
56. Lis-Balchin, M.; Hart, S. L.; Deans, S.G. - Pharmacological and antimicrobial studies on different tea-tree oils (Melaleuca alternifolia, Leptospermum scoparium or Manuka and Kunzea ericoides or Kanuka), originating in Australia and New Zealand. Phytotherapy Research, 2000, v. 14, p. 623–629.
57. Mendes, J. M. Investigação da atividade antifúngica de óleo essencial de Eugenia coryophyllata Thunb.sobre cepas de Candida tropicalis. 2011. 78p. Dissertação (Mestrado em Produtos Naturais e Sintéticos Bioativos – Concentração: Farmacologia). Universidade Federal da Paraíba, João Pessoa, PB.
58. Mertas, A.; Garbusińska, A.; Szliszka, E.; Jureczko, A.; Kowalska, M.; Król, W. The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-Resistant Candida albicans Strains. BioMed Research International, v.2015, Article ID 590470, 2015.
59. Mondello, F.; De-Bernardis, F.; Girolamo, A.; Salvatore, G.; Cassone, A. - In vitro and in vivo activity of tea tree oil against azole susceptible and resistant human pathogenic yeasts. Journal of Antimicrobial Chemotherapy, 2003, v. 51, p. 1223-1229.
60. Moreira Filho, H.E; Goltcher, A. 1972 - Plantas medicinais I. Curitiba: Imprensa da Universidade Federal do Paraná. 103 p
61. Nelson, R.R.S. In -vitro activities of five plant essential oils against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium Journal of Antimicrobial Chemotherapy, 1997, v. 40, p. 305-306,
62. Oliveira FQ, Gobira B, Guimarães C, Batista J, Barreto M, Souza M. Plants species indicated in odontology. Rev Bras Farmacogn. 2007 Sep;17(3):466–76.
63. Oliveira, A.C.M.; Fontana, A.; Negrini, T.C.; Nogueira, M.N.M.; Bedran, T.B.L.; Andrade, C.R.; Spolidorio, L.C.; Spolidorio, D.M.P. - Emprego do óleo de Melaleuca alternifolia Cheel (Myrtaceae) na odontologia: perspectivas quanto à utilização como antimicrobiano alternativo às doenças infecciosas de origem bucal. Revista Brasileira de Plantas Medicinais, Botucatu, 2011, v.13, n.4, p.492-499
64. Oliveira, JB., Perfil de sensibilidade de Staphylococcus sp. frente à Cymbopogon citratus stapf (capim cidrão): estudo experimental in vitro e in vivo.; Dissertação de mestrado, 2016
65. Oliveira, TR de. Avaliação da toxicidade "in vivo", atividade antifúngica e efeito anti-proliferativo do óleo essencial de Melaleuca spp. (Tea tree, Cajuput e Naiuli) sobre espécies do gênero Candida. 2019. 1 recurso online (82 p.). Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Piracicaba, SP.
66. Padovan A, Keszei A, Ko¨llner TG, Degenhardt J, Foley WJ (2010) The molecular basis of host plant selection in Melaleuca quinquenervia by a successful biological control agent. Phytochemistry 71:1237–1244. doi:10.1016/j.phytochem.2010.05.013
67. Peña, E.F. 1962 Melaleuca alternifolia oil. Its use for trichomonal vaginitis and other vaginal infections. Obstetrics and Gynaecology 19, 793-795.
68. Puppin, D de G P B. Ação antifúngica e toxicidade do óleo essencial de Elionurus muticus (capim-limão brasileiro). 2018. 1 recurso online (50 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Piracicaba, SP.
69. Saller R, Berger T, Reichling J, Harkenthal M. Pharmaceutical and medicinal aspects of Australian tea tree oil. Phytomedicine. 1998;5(6):489–95
70. Santamaria, M J; Petermann, K D; Vedovello, S A; Degan, V; Lucato, A; Franzini, C M. Antimicrobial effect of Melaleuca alternifolia dental gel in orthodontic patients. Am J OrthodDentofacialOrthop,145(2):198-202, fev. 2014.
71. Santiago JA; Cardoso MG; Batista LR; Santiago WD; Passamani FRF; Rodrigues LMA; Nelson DL.; Effect of the essential oils from Melaleuca alternifolia, Melaleuca quinquenervia and Backhousia citriodora on the synthesis of ochratoxin A by Aspergillus niger and Aspergillus carbonarius isolated from tropical wine grapes. J Food Sci Technol (January 2018) 55(1):418–423 https://doi.org/10.1007/s13197-017-2857-4
72. Santos EB, Dantas GS, Santos HB, Diniz MFFM, Sampaio FC. Etnobotanical studies of medicinal plants for oral conditions in the municipality of João Pessoa, Brazil. Rev Bras Farmacogn. 2009 Mar;19(1B):321–4.
73. Sardi JCO, Scorzoni L, Bernardi T, Fusco-Almeida AM, Giannini MJSM. Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. J Med Microbiol. 1o de janeiro de 2013 62(Pt 1):10–24.
74. Sartoratto A, Machado ALM, Delarmelina C, Figueira GM, Duarte MCT, Rehder VLG. Composition and antimicrobial activity of essential oils from aromatic plants used in Brazil. Braz J Microbiol. dezembro de 2004;35(4):275–80
75. Satchell, A.C.; Saurajen, A.; Bell, C. et al. Treatment of interdigital Tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo - controlled, blinded study. The Australasian Journal of Dermatology, 2002, v. 45, p. 175 –178
76. Silva FM, Paula JE, Espindola LS. Evaluation of the antifungal potential of Brazilian Cerrado medicinal plants. Mycoses. 52(6):511–17, 2009.
77. Silva, S.R.S.; Demuner, A.J.; Barbosa, L.C.A.; Andrade, N.J.; Nascimento, E.A.; Pinheiro, A.L. - Análise dos Constituintes Químicos e da atividade antimicrobiana de Melaleuca alternifolia Cheel. Revista Brasileira de Plantas Medicinais, 2003, v. 6, p. 63-70
78. Souli M, Galani I, Giamarellou H (2008) Emergence of extensively drug-resistant and pandrug-resistant Gram-negative bacilli in Europe. Euro Surveill 13(47):1-11.
79. Southwell IA, Stiff IA. Ontogenetical changes in monoterpenoids of Melaleuca alternifolia leaf. Phytochemistry. 1989 Jan 1;28(4):1047–51.
80. Syed, T.A.; Qureshi, Z.A.; ALI, S.M. et al. Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream. Tropical Medicine & International Health, 1999, v. 4, p. 284 -287.
81. Tempone AG, Sartorelli P, Teixeira D, Prado FO, Calixto IA, Lorenzi H, Melhem MS. Brazilian flora extracts as source of novel antileishmanial and antifungal compounds. Memórias do Instituto Oswaldo Cruz. 2008, 103(5): 443-449.
82. Tong, M.M.; Altman, P.M.; Barnetson, R.S. Tea tree oil in the treatment of Tinea pedis. The Australasian Journal of Dermatology, 1992, v. 33, p. 145 -149.
83. Veiga Junior, FV; Pinto AC; Maciel MAM. Plantas medicinais: cura segura? Quím Nova. 2005; 28(3): 519-528.
84. Walker, M. Clinical investigation of Australian Melaleuca alternifolia oil for a variety of common foot problems. Current Pediatry, v. 43, p. 28-34, 1972
85. Wheeler G.S., Pratt P.D., Giblin-Davis R.M., K.M.Ordung; Intraspecific variation of Melaleuca quinquenervia leaf oils in its naturalized range in Florida, the Caribbean, and Hawaii Biochemical Systematics and Ecology, 2007, 35, p. 489-500.
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